[4] Highway 25 begins at the northern section of SH-2 at the unincorporated place of Pyramid Corners in Craig County.

The road passes north of Timber Hill en route to Bluejacket.

[3] Like its western twin, the eastern SH-25 is arrow-straight, running due east–west, and experiences no gains or drops of elevation.

[5] This Highway 25 begins three miles (5 km) east of Grove, where SH-10 makes a 90° turn from east–west to north–south; SH-25 continues its east-west path.

The highway passes through rural northeastern Delaware County, running through the Cowskin Prairie.