SH-76 begins north of the Texas border in Love County, south of Leon.

West of Wilson, SH-76 has a two-mile (3 km) concurrency with US-70, after which it splits off and runs through Healdton.

Fifteen miles north of here, it has a four-way-stop controlled intersection with SH-39 west of Dibble.

Bailey Turnpike Spur, and then meets the western terminus of State Highway 130 west of Newcastle.

SH-76 first appeared on the 1932 state highway map, originally running from US-70 south of Healdton to SH-22 (now SH-7) at Ratliff City.