The Old Main Street Historic District in Racine, Wisconsin is an area including a section of Main Street and which is roughly bounded by Second St., Lake Ave., Fifth St., and Wisconsin Ave.

It is a 17-acre (6.9 ha) area with elements dating back to 1847.

It was listed on the National Register of Historic Places in 1987.

[1] In 1987, it included 73 buildings deemed to contribute to the historic character of the area, most built during the 1879s to 1920s, and 22 non-contributing buildings.

It comprises portions of eight blocks.