[4] He was named in August 2005 as one of Marvel's "Young Guns," a group of artists that included Jim Cheung, David Finch, Trevor Hairsine, Adi Granov, and Steve McNiven, which according to Marvel Editor-in-Chief Joe Quesada, exhibited the qualities that make "a future superstar penciller."

One of Coipel's first major works at Marvel was House of M, an eight-issue New Avengers/X-Men crossover limited series with writer Brian Michael Bendis.

Coipel was then announced as artist on a new Thor ongoing series that launched in July 2007 with writer J. Michael Straczynski.

With Guinness officials on hand to monitor their progress, writer Mark Millar began work at 9am scripting a 20-page black and white Superior comic book, with Coipel and the other artists appearing on stage throughout the day to work on the pencils, inks, and lettering, including Dave Gibbons, Frank Quitely, John Romita Jr., Jock,[7] Doug Braithwaite, Ian Churchill, Duncan Fegredo, Simon Furman, David Lafuente, John McCrea, Sean Phillips and Liam Sharp,[8] who all drew a panel each, with regular Superior artist Leinil Yu creating the book's front cover.

The book was completed in 11 hours, 19 minutes, and 38 seconds, and was published through Icon on November 23, 2011, with all royalties being donated to Yorkhill Children's Foundation.