The club's first meeting took place on 28 February in St Patrick's Hall opposite the Sacred Heart Church.

Omagh contested the Tyrone Senior Football Championship final on four occasions before eventually winning the cup for the first time in 1948, beating Clogher Éire Óg GAC 1–3 to 0–2.

In early 1962, the Omagh St Enda's club purchased 13 acres (53,000 m2) of land at Lisnelly located near the Gortin Road.

Justin McMahon went on to win an All-Star for the full-back position in the same year, the first St Enda's club man to achieve the award.

A last-minute goal from Ronan O'Neill sealed victory and bridged a 26-year gap since the club's last senior championship triumph in 1988.