[1] Protagonist Aina Akemiya searches for the Grail in order to increase her chest size, as she feels uncomfortable about her small breasts.

[3] The goal of the game is to search for and obtain the "Holy Grail of Beauty", whilst defeating monsters and avoiding traps through utilizing items, armor, and weapons.

[2] Through defeating monsters in the dungeon, players accumulate Omega Power in addition to experience points; this increases Aina's chest size.

[6] The game is set in the Anberyl Girls Academy, where a rumor of a "Holy Grail of Beauty (美の聖杯)", an object that is said to be able to grant any wish, has surfaced.

[2] Beginning the game's storyline, Aina and Nako head into a nearby dungeon in order to find the grail but are immediately separated.

[11] Initial copies of the game include the "Lightning Malance" weapon and "Butt Shield" armor; unlike the other in-game equipment, these can be repurchased upon losing them in a dungeon.

[13] Richard Eisenbeis of Kotaku summed up the game as "an odd mix of breast-filled fanservice and unforgiving dungeon crawling".

[3] He wrote that players who enjoy fanservice or challenging gameplay may like Omega Labyrinth, but the death system (where missions must be completed in one go) and limited item capacity were criticized as too difficult and too frustrating, respectively.

In Omega Labyrinth Z, the protagonists explore a mysterious new cave at Anberyl Girls Academy, which is opened only on the anniversary of the school's founding.

A third game, Omega Labyrinth Life, was released worldwide on August 1, 2019 for Nintendo Switch and PlayStation 4, and for Steam on December 10.

[26][27] The PlayStation 4 version, which was renamed Labyrinth Life, is censored; some sexual content is removed or replaced, and some nude scenes have obscuring steam added.