[7] Opening on September 14, 1988, it was the tallest building in North Carolina, until 1992 when it was surpassed by the Bank of America Corporate Center.

First Union Center, named for its main occupant, would include an 850,000 square feet (79,000 m2) 34-story granite and glass skyscraper[8] called Two First Union Center, which was to be Art Deco and the city's first postmodernist office tower.

Unlike nearby buildings with flat roofs, the JPJ Architects design used a roof where "[t]he top is rounded, a bold arch rising above the setback sections that enliven the principal facade ... this one looks like an old radio".

[14] On October 18, 1990, the 22-story, 410-room Omni Charlotte held a ribbon cutting, though only eight floors of rooms were ready and fourteen stories had been completed.

[21] Although Wells Fargo is the largest tenant, with 686,834 square feet (63,809.0 m2), or 70 percent of the space, and the namesake of the building, it is occupied by several large North Carolina businesses and national law firms.

[5] In November 2012 it was announced that 1,500 Wells Fargo Securities employees would be relocated from the building to 550 South Tryon into a new 300,000 square feet (28,000 m2) space.

[25] Starwood Capital Group of Greenwich, Connecticut and Vision Properties of Mountain Lakes, New Jersey announced plans to buy the building in February 2013.

The company has been consolidating its Charlotte footprint with leasing the entire 300 South Brevard building,[26] expanding their employee space at the Duke Energy Center following Duke's departure,[27] and relocating additional employees in Three Wells Fargo Center.