[7] The same day, the Ford government announced that the site would be closed immediately and permanently, without attempting repairs due to the pending relocation.

The Communications room contained a number of computerized displays, including a very popular tic-tac-toe game, run on a PDP-11 minicomputer.

[16] The Ontario Science Centre later amended the contract to specify that all goods sold to Oman would be produced in North America.

The Agents of Change transformation was completed 2007, culminating with the opening of the Weston Family Innovation Centre and the Teluscape plaza.

[19] In response to the COVID-19 pandemic in Ontario, the Science Centre received $500,000 from the Government of Canada to promote COVID-19 vaccine uptake among children and their families.

[20] Due to structural decay, which required closing of the pedestrian bridge leading to the exhibits, a shuttle bus line ran from 2023 until the Don Mills site's closure, bringing people from the main entrance to Level 6, the main exhibit area at the bottom of a ravine.

On April 18, 2023, Doug Ford, the premier of Ontario, announced the provincial government's plan to replace the existing Science Centre with a new facility on the Toronto waterfront.

[2][3][4] The proposed new location would be substantially smaller than the current one, requiring the Science Centre to downsize[23] and potentially remove certain exhibits.

[24] Toronto City Council strongly opposes the Ontario provincial demolition plans, and is investigating alternative ways to continue museum operations in the current location.

[5] The Architectural Conservancy of Ontario (ACO) and Toronto Society of Architects (TSA) have issued separate statements opposing the demolition of the original buildings.

[27] On June 21, 2024, the Ministry of Infrastructure announced that the Science Centre's Don Mills location was to be closed effective immediately.

An engineering report[28] made public the same day had concluded that 2-6% of the buildings' roofs had been compromised due to water ingress.

The report included a recommendation to restrict access to occupied spaces below the compromised roof panels, followed by reinforcement or replacement by October 31.

[31] Instead of repairs, the Ford government said it would focus on its previously-announced plans to relocate the centre to Ontario Place, with a scheduled opening date of 2028, and thus close the Don Mills facility immediately.

The province said it would seek a temporary location to host the centre, with a current target opening date of January 2026.

[8][32] The decision to close the Don Mills site instead of repairing it was met with significant opposition by community leaders, Moriyama Teshima Architects (the architectural firm founded by the Centre's designer), and Ford's political opponents.

[39] The Great Hall is an event venue at the Ontario Science Centre and is home to Cloud, a massive, computer-controlled kinetic sculpture by Toronto installation artist David Rokeby, which consists of an array of blue and transparent squares that rotate in various ways to simulate the three states of matter: solid, liquid and gas.

Lotic Meander by Stacy Levy is an outdoor installation in polished and blasted granite and cast glass set into the solar terrace of the Ontario Science Centre.

As originally built, the Science Centre had a large fountain area directly in front of the entranceway, located to create a traffic roundabout.

The exhibition features eight areas that comprise different interactive components, historical artifacts, informational walls, documentary videos and more.

In addition to detailing anatomy, the exhibit explores the possibilities of the human body with activities to simulate the experiences of adventure-seekers, elite athletes, and extreme-sports enthusiasts.

There are more than 80 exhibits in the hall, which were all developed and built by the Science Centre's staff with input from more than 120 neuroscience, physiology, bio-mechanics and sports medicine experts.

[55] The Cohon Family Nature Escape is an outdoor exhibit, situated within the Don River valley to the rear of the science centre.

The exhibit features a giant Baltimore oriole nest, concrete wall canvas for moss graffiti, and a playground slide made from a fallen 125-year-old eastern white pine.

The exhibit includes a 464-year-old Douglas fir, with markings on its growth rings denoting notable world events during the tree's lifetime.

[55] The Space Hall was refurbished in the late 2000s and features meteorites from Mars and one of the few Moon rocks on public display in Canada.

[55] The Weston Family Innovation Centre houses Pipe Dreams by Bruce Shapiro, a bubble art installation.

[63] In his CBC news satire program, Rick Mercer visited numerous scientists' exhibits, took part in a wildlife conservation show, and partook in a psychological fear study during a workshop there.