[1] In particular, both the researchers and participants know which treatment is being administered.
[1] This contrasts with a double-blinded trial, where information is withheld both from the researchers and the participants to reduce bias.
[2][3] Open-label trials may be appropriate for comparing two similar treatments to determine which is most effective, such as a comparison of different prescription anticoagulants,[4] or possible relief from symptoms of some disorders when a placebo is given.
[5] An open-label trial may still be randomized.
Open-label trials may also be uncontrolled (without a placebo group), with all participants receiving the same treatment.