The operation was directed by the Supreme Allied Commander in the South West Pacific Area (SWPA), General Douglas MacArthur, whose forces had advanced along the northeast coast of New Guinea and occupied nearby islands.
This strategic plan, which was never formally adopted by the US Joint Chiefs of Staff but was ultimately implemented, called for the following: The protracted battle for Guadalcanal, followed by the unopposed seizure of the Russell Islands (Operation Cleanslate) on 21 February 1943, resulted in Japanese attempts to reinforce the area by sea.
The disastrous losses suffered by the Japanese prompted Admiral Isoroku Yamamoto to initiate Operation I-Go, a series of air attacks against Allied airfields and shipping at both Guadalcanal and New Guinea, which ultimately resulted in his death on 18 April 1943.
The Joint Chiefs responded with a directive that approved the plan if forces already in the theatre or en route were used, and the implementation was delayed by 60 days.
In the midst of Operation Cartwheel, the Joint Chiefs met with President Franklin Roosevelt and British Prime Minister Winston Churchill at the Quadrant Conference in Quebec City in August 1943.
The campaign, which stretched into 1944, showed the effectiveness of a strategy of avoiding major concentrations of enemy forces and instead aiming to sever the Japanese lines of supply and communication.
The Japanese Navy decided to try to save Rabaul by sending hundreds of airplanes from aircraft carriers based at Truk in December 1943 to counter the US and Australian bombers.