[4] During the 1980s and 90s the O&C building was used to house and test Spacelab science modules before their flights aboard the Space Shuttle.

On January 30, 2007, NASA held a ceremony to mark the transition of the building's high bay for use by the Constellation program.

The building would serve as the final assembly facility for the Orion crew exploration vehicle.

[6] Renovations totaling $55 million took place from June 2007 through January 2009,[7] at which point Lockheed Martin became the operator of the facility for Orion production.

[8] The Orion spacecraft for Artemis 1 completed its assembly in this location and was moved to the Multi-Payload Processing Facility on January 16, 2021.