Ophain-Bois-Seigneur-Isaac (Walloon: Opin) is a village of Wallonia and a district of the municipality of Braine-l'Alleud, located in the province of Walloon Brabant, Belgium.

Some popular spots to see are La grange, Ferme du Moulin à Eau, Carrefour express, Place d'Ophain, Chez Detant, and Chateau Bois Seigneur.

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