O. novo-ulmi came in contact with various amounts of highly susceptible host species in Europe, western Asia and North America making it easier to spread Dutch Elm Disease.

The spores are easily transferred via twig crotches where they obstruct vessels by gums, tyloses, fungal material and foliage wilts, causing the tree to die.

[4] Logs that contain both the fungi and beetles can transmit the pathogen to native species at much higher rate and cause a greater range for invasion.

This can occur naturally through storms, animal activity, or human interventions such as pruning or other tree care practices.

O. novo-ulmi infestation can spread rapidly, causing severe damage and death to susceptible elm trees.

Effective management strategies, such as tree removal, pruning, and applications, may be used to control the spread of the disease in affected areas.