Ophir is now abandoned, but serves as a checkpoint in the Iditarod Trail Sled Dog Race.

An airport with a single gravel runway exists at the village, built prior to 1949.

There are a number of creeks near Ophir, all on the west bank of the Innoko, where gold placers were located starting about 1906.

The original Iditarod trail ran above Ganes Creek in the summer, down the Innoko valley in the winter; the current race trail goes through the old townsite, which was destroyed in a brush fire started by a camper in the 1970s, and is a rest stop.

Further downriver, on the east side, there were mining operations at Folger, Cripple, Bear and Colorado Creeks.