Opodepe is a municipality in the state of Sonora in north-western Mexico.

[1] The municipal seat is Opodepe.

The municipal area is 2,804.25 km2 with a population of 2,842 registered in 2000.

[2] Neighboring municipalities are Benjamín Hill, Santa Ana, Cucurpe, Arizpe, Banámichi, San Felipe de Jesús, Carbó, Rayón and Trincheras.

This article about a location in the Mexican state of Sonora is a stub.