Other settlements with smaller numbers of inhabitants may also be found, as well as ancient Mayan sites such as Cuello, Lamanai, Noh Mul and Chan Chich.

The Rio Bravo Conservation and Management Area, a large private nature reserve in the Yalbac Hills, is also located in this district.

The land is highly cultivated with sugar cane, sorghum, rice, corn and vegetables, with a significant amount of this agriculture done by Mennonite farmers.

Industry in Orange Walk was previously dominated by logging for over a hundred years until the refugees of the Caste War arrived in the late 19th century.

The forts were built in the 19th century after battles between earlier Mayan inhabitants of the district, most notably Marcus Canul and his Icaiche Indians, and settlers.