It arises adjacent to the church of Santa Lucia, and is notable for its collection of frescoes.
The oratory arose at the site used as a church cemetery, but granted to confraternity of San Rocco.
The lower hall of the oratory is richly frescoed with scenes of the life of St Roch.
The frescoes were completed between 1536 and 1545 by the painters Domenico Campagnola, Girolamo Tessari, Gualtiero Padovano, and Stefano Dall'Arzere.
The main altar is made with polychrome marble, and the altarpiece on display is a Madonna with Saints (1697) by Alessandro Maganza.