It is focused on making public and private investments in the Healthcare and Biotechnology industries.

OrbiMed is considered one of the world's largest dedicated healthcare investment firms.

[2][4][7] In 2007, OrbiMed expanded into Asia, opening offices in Shanghai and Mumbai.

In 2010, the firm expanded into the Middle East, opening an office in Herzliya, Israel.

[8] In December 2017, Isaly stepped down from his role as managing partner of OrbiMed due to allegations of sexual harassment raised by former female employees.