The Orchestre symphonique de Mulhouse is a French symphonic orchestra based in Mulhouse, in the Alsace region.
The Orchestre symphonique de Mulhouse has its origins in the small municipal orchestra founded in 1867 in the Alsatian city of Mulhouse.
The orchestra divides its duties between its symphonic season at La Filature and opera performances at the Opéra national du Rhin (whose services it shares with the Orchestre philharmonique de Strasbourg).
In June 2022, Christoph Koncz first guest-conducted the orchestra.
In September 2022, the orchestra announced the appointment of Koncz as its next music director, effective September 2023, with an initial contract of 3 years.