Oregon Route 164 is an Oregon state highway running from Interstate 5 in Marion County north of Millersburg to I-5 at Millersburg in Linn County.

It is 8.54 miles (13.74 km) long and runs north–south, primarily functioning as a loop road to Jefferson.

OR 164 begins at an intersection with I-5 approximately 6 miles (9.7 km) north of Millersburg.

It heads southeast and south to Jefferson, and then turns southwest to rejoin I-5 at Millersburg.

After the completion of the Willamette Valley section of Interstate 5 in the 1960s, US 99E between Salem and Albany was realigned to travel as one co-signed road with the new freeway.