Oregon Route 273 is an Oregon state highway running from OR 66 near Ashland to Interstate 5 near the California state line.

It is 12.42 miles (19.99 km) long and runs north–south parallel of I-5, entirely within Jackson County.

OR 273 was established in 2003 as part of Oregon's project to assign route numbers to highways that previously were not assigned.

OR 273 begins at an intersection with OR 66 approximately four miles southeast of Ashland and heads south, intersecting with I-5 at I-5 Exit 6 and continuing to I-5 Exit 1, where it ends.

This article relating to the United States Numbered Highway System is a stub.