Oregon Route 380 (OR 380) is an Oregon state highway running from Prineville to Paulina.

It is 55.49 miles (89.30 km) long and runs east–west, entirely within Crook County.

OR 380 begins at an intersection with U.S. Route 26 (US 26) at Prineville and heads east through Post to Paulina, where it ends at the Beaver Creek Bridge.

[2] OR 380 was established in 2002 as part of Oregon's project to assign route numbers to highways that previously were not assigned.

The entire route is in Crook County.