Oregon Route 74 is an Oregon, U.S. state highway running from Interstate 84 in Gilliam County to U.S. Route 395 in Umatilla County.

Part of OR 74 is included in the Blue Mountain Scenic Byway.

OR 74 begins at an intersection with I-84 approximately 11 miles (18 km) east of Arlington at Heppner Junction.

It heads southeast through Ione to Lexington.

At Lexington, OR 74 overlaps OR 207 and continues southeast to Heppner.