It is found in the upper Amazon Basin in Bolivia, western Brazil, Colombia, Ecuador, and Peru.

[2] It is a very common terrestrial frog of primary and secondary tropical moist forest, also to be found in clearings, open areas and banana groves.

[1] Oreobates quixensis are large among the species of the genus Oreobates with adults measuring 35–63 mm (1.4–2.5 in) in snout–vent length.

The head is large and wider than long; the snout is short.

The dorsum is pale brown to dark brown with purple tonalities and cream flecks; the skin is granular, with round keratinized granules and small, sparse, prominent, and enlarged warts.