Substantial television roles have included Star Trek: Picard (2022), Into the Badlands (2016 - 2019), Mistresses (2008 - 2010), Jo (2013), American Odyssey (2015) and Bosch Legacy (2025)[6].

Notable feature film work has included The Foreigner (2017) with Pierce Brosnan and Jackie Chan, Rose Plays Julie (2019) with Aiden Gillen, The Price of Desire (2015), A Love Divided (1999) and Silent Grace (2001)[7].

[9] Returning to Dublin after studying in Paris, she performed the role of Adela in House of Bernarda Alba in 1989[10] and Natasha in a 1990 production of Three Sisters, both at the Gate Theatre.

[16] In late 2013, she appeared as the Countess Vera Rossakoff in the television adaptation of The Labours of Hercules, part of the final series of Agatha Christie's Poirot alongside David Suchet.

[19] In 2015, Brady appeared as architect Eileen Gray in Irish director Mary McGuckian's The Price of Desire,[13] which was in festivals in 2016 (and found a digital distributor in 2020).

[21][22] Brady won the 1999 award for Best Actress at the Monte Carlo International Film and Television Festival for her starring role as Sheila Cloney in the RTÉ-BBC co-production, A Love Divided .

[a] More than 25 years later, it was noted that one of these images of Brady, posing as part of a dancing couple, was the basis of the main figures in a widely-known painting, The Singing Butler, by artist Jack Vettriano.

The identification of the pose study in the Illustrator's Manual with Vettriano's painting led to media reporting that he "owed his composition in part" to that publication.

[27][28][b] In 2001, Brady moved to Los Angeles, where she met English photographer Nick Brandt, whom she married in December 2002 in the Chyulu Hills of Kenya.