During the 1970s and 1980s she worked with the most popular Italian actors as Ugo Tognazzi, Vittorio Gassman, Marcello Mastroianni, Carlo Verdone, Renato Pozzetto, Paolo Villaggio, Francesco Nuti, Giancarlo Giannini in successful comedies as Nobody's Perfect, Bonnie and Clyde Italian Style, Rich and Poor, All the Fault of Paradise, Me and My Sister, Tonight at Alice's, and also dramatic movies as The Last Woman, The Bishop's Bedroom, Nest of Vipers, Break Up, Tales of Ordinary Madness and The Future Is Woman.

Her best known movies in Europe are Swann in Love in which she acted with Jeremy Irons and Alain Delon, The Bilingual Lover where she starred with Javier Bardem, Hotel, with Salma Hayek, David Schwimmer, Lucy Liu, Burt Reynolds, and John Malkovich, and The Tulse Luper Suitcases, Part 1: The Moab Story, a multimedia project by Peter Greenaway.

In the United States she has worked with directors such as Woody Allen, John Landis, Eugene Levy, Buddy Giovinazzo and James Toback.

[8] In 2015, the Italian court of Pordenone sentenced her to eight months in prison for having cancelled a theatrical performance following a health problem, which did not prevent her from participating in a social dinner with Vladimir Putin in Saint Petersburg in December 2010.

[5] Muti has three children: Naike Rivelli (born 1974), a fashion model, singer, and actress; a son, Andrea, and a second daughter, Carolina, both from her marriage to Fachinetti.