OROV was originally reported in Trinidad and Tobago in 1955 from the blood sample of a fever patient and from a pool of Coquillettidia venezuelensis mosquitoes.

[1] In 1960, OROV was isolated from a sloth (Bradypus tridactylus) and a pool of Ochlerotatus serratus mosquitoes in Brazil.

[2] The virus is considered a public health threat in tropical and subtropical areas of Central and South America, with over half a million infected people as of 2005.

[3] OROV is considered to be an arbovirus due to the method of transmission by the mosquitoes Aedes serratus and Culex quinquefasciatus among sloths, marsupials, primates, and birds.

[5] Through phylogenetic analysis of nucleocapsid genes in different oropouche virus strains, it has been revealed that there are three unique genotypes (I, II, III) which have been spreading through Central and South America.

[2] OROV is considered to be an arbovirus due to the method of transmission by the mosquitoes Aedes serratus and Culex quinquefasciatus among sloths, marsupials, primates, and birds.

In UV-inactivated OROV, virus-receptor binding was not enough and that viral uncoating and replication were needed to induce apoptosis.