The Orsini-Colonna castle (Italian Castello Orsini-Colonna) is a castle in Avezzano, Province of L'Aquila (Abruzzo).

Following its restoration, now it is used as a picture gallery and multifunction space.

[2] The squared building is protected by four circular towers at each corner.

A circular tower was also in the middle of the internal courtyard, now demolished.

The current main entrance was built by the Colonna family to celebrate the battle of Lepanto.