Lorenzo and his wife Lydia Folger Fowler lectured frequently with Orson on the subject of phrenology.

[4] At the same time, the phrenological journal edited by Fowler and his brother expressed strong abolitionist sentiments, calling slavery a "a monstrous evil.

[6] For instance, in "Hereditary Descent" (1843), Fowler wrote that Jewish people were hereditarily acquisitive, deceitful, and destructive[7] (phrenology believes that none of these "organs" are negative as such, but all can be used for good).

His sister, Charlotte Fowler Wells, and her husband, were involved in the publishing house, and after it became a stock company, she served as president.

Fowler was married three times: to Mrs. Eliza (Brevoort) Chevalier; to Mrs. Mary (Aiken) Poole; and to Abbie L. Ayres.

[citation needed] Orson stood for children's rights when child labor was quite acceptable in the burgeoning industrial factories of his country.

[citation needed] Fowler as a book seller and publisher was crucial in the original publication of Walt Whitman's Leaves of Grass and other works.