Political and strategic reasons motivated the frequent moves of the pope and Roman Curia during this period, and other destinations include Viterbo and Perugia.
According to the Catholic Encyclopedia, "on account of its position, Orvieto was often chosen by the popes as a place of refuge and Adrian IV fortified it.
The structure became a papal palace during Urban IV's two-year stay in Orvieto, starting October 18, 1262, although it may not have been completed until Gregory X (1271–1276) took up residence there on July 26, 1272.
Nicholas IV was elected Podestà and Capitano del Popolo of Orvieto, the first pope to hold civic offices in the city.
Nicholas V (1447–55) in a 1449 letter gave money for the restoration of the Episcopal Palace and authorized Fra Angelico to begin painting in the Cappella Nuova of the Cathedral.
Preparing for a possible siege of the city, he ordered the Pozzo di San Patrizio ("Well of St. Patrick) constructed by architect-engineer Antonio da Sangallo the Younger.
According to the Catholic Encyclopedia, "in the palace of the popes, built by Boniface VIII, is the civic museum, which contains Etruscan antiquities and works of art that are, for the greater part, from the cathedral.