The Osage Fork Gasconade River is a stream in Wright, Webster and Laclede counties in the Ozarks of southern Missouri.

The stream headwaters arise in Webster County near the intersection of Missouri routes C and P about seven miles north of Seymour.

[3][4] The stream flows north past High Prairie where it turns to the northwest.

It passes about 3.5 miles east of Niangua and continues to the northeast passing under Missouri Route ZZ just west of Rader to enter Laclede County.

It meanders to the southeast and crosses into the northwest corner of Wright County before returning to a northeast direction back into Laclede County adjacent to the community of Pease.