Osaka YMCA International School (大阪YMCAインターナショナルスクール, Ōsaka YMCA Intānashonaru Sukūru, OYIS) is an international school in Kita-ku, Osaka, Japan.

OYIS began operations in 2001 and received gakko hojin (private school) status from the Osaka prefectural government in 2012.

OYIS is currently accredited by the International Baccalaureate Organization (IB) and by the US-based Western Association of Schools and Colleges (WASC).

The school was established in September 2001 from a partnership of Osaka city and the YMCA.

William A. Fischel, author of Making the Grade: The Economic Evolution of American School Districts, stated that a version of the OYIS website which had names of students, "at least half of which suggest Japanese parentage", made him conclude that OYIS was not only for North American families.