[1][2] It is a poorly known species only known from few specimens: the holotype from the imprecise type locality, "a small creek tributary to Río Mazaruni" in Guyana, one from similarly imprecise Cayenne in French Guiana,[1][3] and another one from the Nouragues research station in French Guiana.

[4] The specific name zweifeli honors Richard G. Zweifel, an American herpetologist.

[6] The dorsum is grayish lavender in color, while the belly is whitish and has some gray specks.

[3] The habitat requirements and ecology of this are poorly known, but it is assumed to be a subterranean species inhabiting lowland tropical forest.

[1] Predators of Oscaecilia zweifeli include the giant tarantula Theraphosa blondi: an adult tarantula was found with its caecilian prey under a rotten trunk, and it had produced a silk cocoon around the head of the dead animal, which was already partly digested.