Vehicles were primarily produced for the US, Canadian, and Mexican markets, as well as exports for various countries around the world, particularly South America and the Middle East.

Historically the Oshawa plant was the source of all right-hand-drive market GM exports with complete vehicles or knock-down kits shipped to Australia, New Zealand, South Africa, and the United Kingdom until the end of the 1960s.

In August 2017, it was rated highly by its employees in The Best Places to Work in Canada rankings by Indeed, garnering 4th spot overall, and 1st for wages and benefits.

[5] In January 1918, Oshawa became the first Canadian GM plant to minimize the issue of large scale layoffs by cutting the second shift and alternating day- and night-shift workers at two-week intervals.

[6] The plant later moved to the GM Autoplex facilities in the southern part of the city starting production on November 7, 1953.

The plant began the production of high performance 2012 Camaro ZL1 and the 2012 Buick Regal GS in 2012 and will build the 2013 Cadillac XTS in the first quarter of 2012.

In August 2010, the plant began assembling the Chevrolet Equinox in partnership with another GM facility in Ingersoll, Ontario, known as CAMI Automotive.

The metal bodies are made at CAMI, trucked two hours east to Oshawa, where they are inserted on the conveyor just before the paint shop.

The CAMI facility does make Equinox and GMC Terrain from start to finish at their own plant, but they did not have the capacity to put more bodies through paint and general assembly.

The final vehicle, a white GMC Sierra pickup truck, rolled off the assembly line on December 18, 2019.

[10] On November 4, 2020, GM announced "Subject to ratification of the 2020 agreement with Unifor, General Motors plans to bring pickup production back to the Oshawa Assembly Plant.