Oskar Simon (2 January 1845 – 2 March 1882) was a German dermatologist who was a native of Berlin.
During the Franco-Prussian War he was an assistant-surgeon, and in 1872 became a lecturer of skin diseases and syphilis in Berlin.
In 1878 he succeeded Heinrich Koebner (1838-1904) as professor of dermatology at the University of Breslau, and also became chief physician at Allerheiligen Hospital.
Among his students were Albert Neisser (1855-1916), Edmund Lesser (1852-1918) and Eduard Arning (1855-1936).
Oskar Simon died from carcinoma of the stomach on 2 March 1882 at the age of 37.