[5] The present hospital building was completed in 1919 on orders of the last Nizam of Hyderabad, Mir Osman Ali Khan.

It was designed by British architect Vincent Jerome Esch and Nawab Khan Bahadur Mirza Akbar Baig in Indo-Sarcenic style.

Despite concerns over the relocation of the hospital and its potential impact on local heritage, the government is moving forward with the plan to modernize healthcare facilities in Hyderabad.

Additionally, there are fears about the potential loss of the heritage value of the original Osmania General Hospital building.

Legal challenges to the relocation have been filed, and the Telangana High Court issued notices regarding the proposed move in 2024.