The station lies on the shores of Lago Bianco, near the Bernina Pass, between the Engadin and the valley of Poschiavo, in Graubünden.

It is named after the hostel (historically, ospizio in Italian) that lies on the road pass, 50 metres above the station.

Hourly services in both direction operate on this line, throughout the year, despite harsh winter conditions.

The station building dates from the opening, but was extended and adopted its existing form in 1925.

[5][6] As of the December 2023 timetable change,[update] the following services stop at Ospizio Bernina:[7]