[1] Osteoblasts begin the process of forming bone tissue by secreting the osteoid as several specific proteins.

A deficiency of type I collagen, such as in osteogenesis imperfecta, also leads to defective osteoid and brittle, fracture-prone bones.

Another condition is a disturbance in primitive transformed cells of mesenchymal origin, which exhibit osteoblastic differentiation and produce malignant osteoid.

This results in the formation of a malignant primary bone tumor known as osteosarcoma or osteogenic sarcoma.

This malignancy most often develops in adolescence during periods of rapid osteoid formation (commonly referred to as growth spurts).