Otay Centenario is a borough of the municipality of Tijuana in Baja California, Mexico.

It is the result of a merger between the former boroughs of Mesa de Otay and Centenario which took place on January 1, 2014.

[1][2] The borough is located east of the Centro borough and the Zona Río; south of the U.S. border and San Diego's Otay Mesa neighborhood; and north of La Mesa.

The area is noted as the second gastronomic hub of the city, with many restaurants.

The former Centenario borough has the largest number of factories and maquiladoras in the city.