Otto's regiment participated in the 1807 War against Napoleon Bonaparte, and the officer was awarded with an Order of St. Stanislaus of 3rd degree.
September 4, 1815 he was promoted to the rank of staff-captain (of cavalry) (штабс-ротмистр) of a corps stationed in France and aide-de-camp to Russian general Count Mikhail Semyonovich Vorontsov.
February 3, 1829 von Pfeilitzer-Franck was made official for important missions (чиновник для особых поручений) by the Governor-General of Novorossiysk and Bessarabia.
This was the time of a plague epidemic in the South of Russia, and Baron was charged with the mission of preventing its further spread and complete extinction.
He was also appointed as the chief administrator (главный попечитель) of the merchant vessels' navigation in the Azov Sea, and head of the Taganrog Customs district.