When his father, under pressure from Emperor Frederick Barbarossa, retired and entered the Augustinian convent of Lauterberg in 1156, Otto succeeded him in Meissen while his younger brothers Theodoric and Dedi received the March of Lusatia and the County of Groitzsch with Rochlitz.
He had to stand by and watch the emperor's extension of power in the Pleissnerland territory around Altenburg, Chemnitz and Zwickau; moreover he picked an unsuccessful quarrel with the rising burgraves of Dohna in the Eastern Ore Mountains.
Together with Archbishop Wichmann of Magdeburg he joined Emperor Frederick's expedition against the rebellious Saxon duke Henry the Lion in 1179, however, he failed to benefit from his downfall.
Otto's domestic policies were more successful: about 1165 he vested the citizens of Leipzig, located at the crossways of the Via Regia and Via Imperii trade routes, with town privileges and founded the St. Nicholas Church.
He also established Altzella Abbey on the Miriquidi estates on the slopes of the Ore Mountains he had received from the emperor, where silver was discovered near Christiansdorf in 1168.