Karl Friedrich Otto von Gerlach (12 April 1801 – 24 October 1849) was a German theologian and pastor from Berlin.
Otto von Gerlach first studied law, then theology in Berlin, Heidelberg and Göttingen.
He was influenced by the Great Awakening movement and was a member of the Christlich-deutsche Tischgesellschaft of Adolph von Thadden (1796–1882).
In 1844, he was found guilty of mistreating a maid, which led to her death, and sentenced to one year in prison, but he never had to serve his time.
Otto von Gerlach published a major rewrite of the old and new testament after Martin Luther, and translated several important texts of the Great Awakening movement from English into German, including works by John Wesley (1703–1791), Richard Baxter (1615–1691), and Thomas Chalmers (1780–1847).