The project chair, Sir John Bell, said that the project aims "to try and create a sandbox for testing and evaluating these early diagnostic or prevention strategies across a large population of people ... And we'll be able to use that population to help us evaluate these new tools, diagnose disease early, prevent disease more effectively, and intervene at an earlier stage".
Participants are asked to complete a questionnaire about their health and lifestyle, and to attend a clinic to give a blood sample and have physical measurements taken.
[14][15] Part of each blood sample is used for DNA analysis, with the results stored in the participant's record; the project may also use SNP array and genomic sequencing methods.
[17] As well as providing samples and personal data from questionnaires, surveys and feedback, participants agree to allow the project to access their present and future records held by the NHS.
[16] The project has the support of the government, the life sciences industry, the NHS, and charities such as Alzheimer's Society, British Heart Foundation, and Cancer Research UK.