SNP array

In molecular biology, SNP array is a type of DNA microarray which is used to detect polymorphisms within a population.

The three mandatory components of the SNP arrays are:[3] The ASO probes are often chosen based on sequencing of a representative panel of individuals: positions found to vary in the panel at a specified frequency are used as the basis for probes.

The most important clinical applications of SNP arrays are for determining disease susceptibility[5] and for measuring the efficacy of drug therapies designed specifically for individuals.

SNP arrays, however, have an additional advantage of being able to detect copy-neutral LOH (also called uniparental disomy or gene conversion).

High density SNP arrays help scientists identify patterns of allelic imbalance.

For example, recent SNP array studies have shown that solid tumors such as gastric cancer and liver cancer show LOH, as do non-solid malignancies such as hematologic malignancies, ALL, MDS, CML and others.

These studies may provide insights into how these diseases develop, as well as information about how to create therapies for them.

[12] Breeding in a number of animal and plant species has been revolutionized by the emergence of SNP arrays.