[3] The official dedication of the hospital took place July 14, 1953 and included a reading of a cablegram from Pope Pius XII.

It read, "Our Holy Father deeply grateful, learned forthcoming inauguration, Our Lady of Bellefonte Hospital, Ashland, Kentucky, sends cordial felicitations.

Imparts Your Excellency, priests, religious, faithful, and hospital staff, fraternal Apostolic Benediction."

[2] The center featured an indoor track and rehabilitation-size swimming pool along with a variety of fitness equipment.

In 1994, OLBH began an outreach program, opening walk-in primary medical care facilities in several outlying communities.

In addition to the original locations, Bellefonte Physician Services today operates primary-care facilities in Ashland, Greenup and Ironton, Ohio.

In an effort to assist in training physicians, OLBH began a resident program in 2002 in conjunction with the University of Pikeville Kentucky College of Osteopathic Medicine.

In 2005, OLBH introduced the Human Motion concept, an approach to musculoskeletal injuries and orthopedic issues and becomes the area's first hospital to offer 64-slice CT technology.

[5] In 2007, hospital comparison information released by the federal government establishes OLBH as the Tri-State-area's leading medical facility in the care of pneumonia and number one in Ashland for two important categories relating to heart failure.

In 2009, HealthGrades, a national independent healthcare ratings organization, presented OLBH with its Pulmonary Care Excellence Award.

[12] Additionally, the hospital received these top quality ratings for treatment of respiratory failure and sepsis, a critical bloodstream infection.

[14] On February 20, 2020, Bon Secours Mercy pushed up the closing date to April 30, 2020, due to lack of staffing.

On January 25, 2021, the fiscal court agreed to sell the building and adjacent property to King's Daughters Medical Center for $3 million.

[20] Addiction Recovery Care (ARC) of Louisa, Kentucky announced in April 2021 that they were considering purchasing the main hospital building and other former OLBH property to develop a residential treatment facility for individuals dealing with substance abuse disorders, as well as reopening the psychiatric and detox units previously operated by OLBH.

After discussions with city of Russell, Greenup County and Kentucky state officials as well as area residents, ARC signed a letter of intent to purchase the property in December 2021.

On March 11, 2022, ARC and Bon Secours Mercy Health announced that a purchase agreement for the OLBH property had been finalized.