The series takes place in a bleak world ruled by mega-corporations and corrupt politicians that prey on the weak and poor members of society.
In this world, all manners of outrageous habits exists: Slaughterbowl (a hyper violent sport comparable to football) and government controlled euthanasia centers are among them.
Her team is composed of cyborg ex-Slaughterbowl Superstar B.D Rickenbacker, the cursed to be immortal Yancy Queeg, and the blue-skinned Dag Skinnard AKA Shock, a mutant with powers of electricity who is out to avenge the death of his girlfriend by Big City enforcers.
On various raids and excursions, the team discovers and obtains proof of the horrible truth; all male mutants taken off-world are killed and their remains destroyed.
The women are kept alive for breeding purposes because mutant children produce a certain enzyme in their heads that has healing properties and can prolong life, keeping them young and vital.
Big City's rich and corrupt desperately want to be inoculated with this serum, named Immortalis, so they joined Boss Angel and outlawed mutantism.
They hijack the ambulance containing Kaine and Yancy, angry that she won't be able to finally end his life of immortality by aging him to death, grabs her bare skin as he yells at her to get up.
grabs a red bucket and puts Yancy's bones and head in it and carries it with him, talking to his old pal as if nothing happened to him.
He invites his former Slaughterbowl teammate Nigel "Killer" Kowalski to join in the struggle and assist him in springing another ex-teammate Professor W. R. Watson.
ORCOM reveals that it was the one who had killed the corrupt City Council members and that it considers itself a mutant and part of their team.
She tells Boss Angel that she is now in charge of Big City and she will allow him to work for her to set things right if he plays along.
They stalk off into the night, wishing that Kaine had kept the team together, clutching the bucket and yelling their battle cry... "Outcasts!
Rickenbacker, Nigel "Killer" Kowalski, and Yancy Queeg (in a bucket) appear in the Lobo 1993 miniseries UnAmerican Gladiators, also written by John Wagner and Alan Grant and drawn by Cam Kennedy.