The Ouysse (French pronunciation: [wis]) is an approximately 41 km (25 mi) long river in the Lot (department) department, south-central France.

It flows west to the village Thémines, from where it continues as a subterranean river through the limestone formations south of Gramat.

It emerges near Rocamadour, about 20 km west from where it submerged, receives its tributary the Alzou and flows into the Dordogne near Lacave.

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