Overland Park Regional Medical Center first opened in December 1978.

[2] In 2002, HCA Inc. announced their purchase of Health Midwest, which included Overland Park Regional Medical Center.

[2][3] In 2014, the hospital completed a $120 million expansion that included a new emergency department and trauma center, a three-story patient tower, and a new parking garage.

[1][2][4] Dr. Raymond Brovont, an emergency room physician at Overland Park was fired in January 2017 after raising concerns that low physician staffing levels at the hospital endangered patients.

Available facilities include an emergency department and level II trauma center, dedicated pediatric emergency department, catheterization laboratory, intensive care unit, labor and delivery, level III neonatal intensive care unit (NICU), and outpatient care.