After playing college football for Wake Forest University, he was selected by the Ravens in the fourth round of the 2003 NFL draft.

Mughelli attended Porter-Gaud School and a letterman in football, basketball, tennis, and track & field.

A fullback in college, Ovie was a first-team All-Atlantic Coast Conference (ACC) selection at that position.

He started every game in his senior year as a Demon Deacon, coming in with the third highest rushing touchdown record in school history.

In 2007, Mughelli signed with the Atlanta Falcons to block for running backs Warrick Dunn and Jerious Norwood.