[1][2] In humans, ovotestes are an infrequent anatomical variation associated with gonadal dysgenesis.
[4] In invertebrates that are normally hermaphroditic, such as most gastropods (snails and slugs) in the clade Eupulmonata, an ovotestis is a common feature of the reproductive anatomy.
Experiments involving the SOX9 gene, which is initiated by the SRY region of the Y chromosome, have shown the gene's requirement for testicular differentiation from the presence of ovotestis formation within XX Sox9 trangenic mice.
(6) Ovotestis within B6-XYPOS mice allow for gonadal development research within the same tissue to take place in ways previously unavailable.
[5][6] An ovotestis or hermaphroditic gland (Latin: glandula hermaphroditica),[7] is found as normal anatomical feature in the reproductive system of some gastropods including such species as the land snail Cornu aspersum.